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Field medications · Adult & pediatric guidance · ALS

Ondansetron (Zofran)

Adult oral/IV treatment and the pediatric age-4-and-older ODT pathway.

OCEMS source summary · Updated 2026-09-16

Check before giving

  • The adult standing order excludes known or suspected pregnancy.
  • Do not let symptom control replace assessment of dehydration, poor perfusion, or an altered level of consciousness.

Use in OCEMS

  • For ongoing nausea/vomiting in the applicable condition order. Treat associated airway risk and dehydration as well as symptoms.
  • The oral dissolving tablet and IV preparation have different dosing instructions.

Adult / adolescent

Indication / routeDose & limits
ODT8 mg (two 4 mg tablets) dissolved orally, once, when pregnancy is not known or suspected.
IV4 mg IV; may repeat 4 mg once after approximately 3 minutes for continued/recurrent symptoms, when pregnancy is not known or suspected.

Pediatric

  • SO-P-090: children age 4 and older may receive one 4 mg ODT tablet dissolved orally, as tolerated.
  • The cited pediatric nausea standing order does not provide routine IV dosing or an ODT dose below age 4. Do not infer a weight-scaled adult regimen.

Pediatric dose by age / weight

  • SO-P-090 applies to ongoing nausea/vomiting. Age, not weight, determines eligibility for this fixed dose.
Age / weightPediatric doseRoute / limit
Younger than 4; any weightNo dose in this pediatric standing orderDo not extrapolate from an adult IV dose
Age 4 and older; any eligible pediatric weight4 mgOne ODT tablet dissolved orally as tolerated

Preparation & reassessment

  • Stock includes 4 mg ODT and 4 mg/2 mL IV preparations. Verify the product and route.
  • Keep suction available when needed. Reassess vomiting, airway protection, perfusion, and treatment response; follow the applicable fluid pathway.