Source: PR-130. Dose rule: 70 mg/kg; route: IV/IO over approximately 15 minutes.
70 mg/kg IV/IO over approximately 15 minutes; maximum 5,000 mg (5 g). Base hospital order required.
For the 5 g Cyanokit described in PR-130, add 200 mL normal saline to produce 25 mg/mL. Rock/invert to mix; do not shake. Do not run other medications simultaneously through the same IV/IO site.
Calculated examples for the exact weights shown, using the named standing-order/procedure formula. Do not round the patient’s weight to the nearest row. For another weight, calculate from the stated formula and apply the limits. These are not the rounded I-20 weight-band volumes.
Volumes are mathematical examples rounded to at most three decimal places. Verify the vial concentration, dose, and measurable syringe volume before administration; follow agency preparation/rounding practice.
Exact weight
Dose — IV/IO over approximately 15 minutes
Volume at 25 mg/mL after reconstitution
3 kg
210 mg
8.4 mL
4 kg
280 mg
11.2 mL
5 kg
350 mg
14 mL
6 kg
420 mg
16.8 mL
8 kg
560 mg
22.4 mL
10 kg
700 mg
28 mL
12 kg
840 mg
33.6 mL
15 kg
1050 mg
42 mL
20 kg
1400 mg
56 mL
25 kg
1750 mg
70 mL
30 kg
2100 mg
84 mL
35 kg
2450 mg
98 mL
40 kg
2800 mg
112 mL
45 kg
3150 mg
126 mL
50 kg
3500 mg
140 mL
60 kg
4200 mg
168 mL
Preparation & reassessment
For the 5 g Cyanokit described by PR-130, add 200 mL normal saline using the transfer spike. Invert/rock for about 60 seconds; do not shake. Confirm a dark-red solution without visible particles.
Remove the patient from exposure, provide high-flow oxygen and airway support, and monitor during infusion.
Reddish skin/mucosal discoloration and increased blood pressure can occur. Notify the receiving team of administration before arrival.